Cathedral of Saint Mary of the Annunciation
Cape Girardeau, Illinois
AddressWilliam Street
DenominationCatholic
Phone+1 573-335-9347
Emailcstrat23@gmail.com
Services
Mass
Sat4:30 PM
Sun7:00 AM, 8:30 AM, 10:30 AM
Tue8:00 AM, 5:15 PM
Mon6:00 AM, 8:00 AM
Wed6:00 AM, 8:00 AM
Thu6:00 AM, 8:00 AM
Fri6:00 AM, 8:00 AM
Last updated June 2026

~2,424
estimated members
Based on ARDA 2020 data, this is likely one of 4 Catholic congregations in Cape Girardeau County, MO, with an average size of approximately 2,424 members. Catholic accounts for 20% of the county's 116 congregations.
Source: ARDA 2020 Religious Congregations & Membership Study
Plan Your Visit
Book an Experience
i
We recommend experiences from our partners and may earn a commission at no cost to you.
Nearby churches in Cape Girardeau
Christ Eveangelical Church
0.2 miEvangelical
South Ellis Street
Grace Church
0.3 miProtestant
610 Independence St
Saint Vincents Church
0.4 miCatholic
South Main Street
Old St Vincent's Catholic Church
0.4 miCatholic
131 S Main St
Mercy Church
0.5 miNon-Denominational
833 Broadway St
First Presbyterian Church
0.5 miPresbyterian
Washington Avenue